Monte Carlo study of secondary electron production from gold nanoparticle in proton beam irradiation

Jeff Gao, Yuanshui Zheng

Abstract


Purpose: In this study, we examined some characteristics of secondary electrons produced by gold nanoparticle (NP) during proton beam irradiation.

Method: By using the Geant4 Monte Carlo simulation toolkit, we simulated the NP at the range from radius (r) of 17.5 nm, 25 nm, 35 nm to r = 50 nm. The proton beam energies used were 20MeV, 50MeV, and 100MeV. Findings on secondary electron production and their average kinetic energy  are presented in this paper.

Results: Firstly, for NP with a finite size, the secondary electron production increase with decreasing incident proton beam energy and secondary buildup existed outside NP. Secondly, the average kinetic energy of secondary electrons produced by a gold NP increased with incident proton beam energy. Thirdly, the larger the NP size, the more the secondary electron production.

Conclusion: Collectively, our results suggest that apart from biological uptake efficiency, we should take the secondary electron production effect into   account when considering the potential use of NPs in proton beam irradiation.

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Cite this article as: Gao J, Zheng Y. Monte Carlo study of secondary electron production from gold nanoparticle in proton beam irradiation. Int J  Cancer Ther Oncol 2014; 2(2):02025.

DOI: http://dx.doi.org/10.14319/ijcto.0202.5


Keywords


Gold nanoparticle; Secondary electron production; Proton

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References


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DOI: http://dx.doi.org/10.14319/ijcto.0202.5

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International Journal of Cancer Therapy and Oncology (ISSN 2330-4049)

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